Male infertility is associated with altered treatment course of men with cancer.
نویسندگان
چکیده
This study aims to evaluate whether cancer treatments differ in infertile men compared to men who have undergone vasectomy and age-matched controls. We analyzed subjects from the Truven Health MarketScan Claims database from 2001 to 2009. Infertile men were identified through diagnosis and treatment codes. Comparison groups included vasectomized men and an age-matched cohort who were not infertile and had not undergone vasectomy. We considered cancer types previously associated with infertility that were diagnosed after the diagnosis of infertility. The treatment regimens were determined based on the presence of claims with CPT codes for chemotherapy (CTX), radiation (RTX) or surgical treatment (ST) for each entity in all study groups. Cases with multimodal treatments were also identified. As a result, CTX was similarly distributed among the infertile, vasectomized, and control groups. In contrast, RTX treatment length was shorter in infertile men. The frequency of multimodal treatment (i.e., radiation and chemotherapy) was twofold lower in men with infertility compared to other men. By focusing on treatment patterns for each cancer type among these groups, the duration of RTX and CTX was shorter in infertile men diagnosed with NHL compared to controls. We conclude that Infertile men diagnosed with cancer and specific cancer types experience different treatment courses, with shorter RTX and less combined RTX/CTX compared to fertile and vasectomized men. These differences could reflect differences in stage at presentation, biological behavior, or treatment responses in infertile men.
منابع مشابه
Pnm-11: Male Infertility and Its Effect on Male Sexuality
a:4:{s:10:"Background";s:514:"Male infertility may occur as a consequence of psychological or physical problems or a combination thereof. On learning of their infertility, patients usually go through an initial emotional crisis. The male response thereafter varies depending on the etiology of the infertility. Male factor infertility threatens the traditional male/father role and results in a fe...
متن کاملI-6: Fertility Preservation in Male Patient with Cancer
Studies suggest that the ability to have biological children is of great importance to many people. The cancer and its treatment often pose a threat to fertility. Rates of permanent infertility and compromised fertility after cancer treatment vary and depend on many factors. Male infertility can result from the disease itself (best documented in patients with testicular cancer and Hodgkin’s lym...
متن کاملPnm-1: Infertility in Obese Men
Background The obesity pandemic has grown to concerning proportions in recent years, not only in the Western World, but in developing countries as well. The corresponding decrease in male fertility and fecundity may be explained in parallel to obesity. Obesity in men is associated with infertility in numerous studies. MaterialsAndMethods In this review article, electronic searches were undertak...
متن کاملInm-6: Evaluate The Supportive Role of Spouse in Infertile Couples Training
Infertility is a life crisis and the most important problem for infertile couples. The inability to bear children is a stressful situation. The most infertile couple experience emotional suffering from infertility. The relation of stress to infertility is long-standing and ambiguous. The reaction of infertile couple in the stressful situations is influenced by the coping strategies for infertil...
متن کاملIL-1ɑ C376A Transversion Variant and Risk of Idiopathic Male Infertility in Iranian Men: A Genetic Association Study
Objective IL-1α produces by sertoli cells and considered as a growth factor for spermatogonia. In this study we investigated the association of C376A polymorphism in IL-1α gene with male infertility in men referring to Kashan IVF center which followed by an in silico approach. MaterialsAndMethods In a case-control study, 2 ml blood was collected from 230 fertile and 230 infertile men. After DNA...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Andrology
دوره شماره
صفحات -
تاریخ انتشار 2018